4nqw

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Current revision (08:43, 11 January 2023) (edit) (undo)
 
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==Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA==
==Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA==
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<StructureSection load='4nqw' size='340' side='right' caption='[[4nqw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4nqw' size='340' side='right'caption='[[4nqw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nqw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0445c, sigK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), rskA, Rv0444c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqw OCA], [https://pdbe.org/4nqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nqw RCSB], [https://www.ebi.ac.uk/pdbsum/4nqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqw OCA], [http://pdbe.org/4nqw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nqw RCSB], [http://www.ebi.ac.uk/pdbsum/4nqw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [[http://www.uniprot.org/uniprot/RSKA_MYCTU RSKA_MYCTU]] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
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[https://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Sigma factor|Sigma factor]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gopal, B]]
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[[Category: Large Structures]]
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[[Category: Shukla, J K]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Anti-sigma factor]]
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[[Category: Gopal B]]
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[[Category: Dna binding]]
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[[Category: Shukla JK]]
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[[Category: Dna binding protein-protein binding complex]]
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[[Category: Promoter dna binding and transcription initiation]]
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[[Category: Sigma factor]]
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[[Category: Transcription initiation]]
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Current revision

Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA

PDB ID 4nqw

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