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1jlo

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[[Image:1jlo.png|left|200px]]
 
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==Solution Structure of the Noncompetitive Skeletal Muscle Nicotinic Acetylcholine Receptor Antagonist Psi-conotoxin PIIIE==
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The line below this paragraph, containing "STRUCTURE_1jlo", creates the "Structure Box" on the page.
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<StructureSection load='1jlo' size='340' side='right'caption='[[1jlo]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_purpurascens Conus purpurascens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlo OCA], [https://pdbe.org/1jlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlo RCSB], [https://www.ebi.ac.uk/pdbsum/1jlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlo ProSAT]</span></td></tr>
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{{STRUCTURE_1jlo| PDB=1jlo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CM3E_CONPU CM3E_CONPU] Psi-conotoxins act on postsynaptic membranes, and act as non-competitive antagonist of nicotinic acetylcholine receptors (nAChR). Is more toxic than Psi-conotoxin PIIIF. Has paralytic activity when injected intraperitoneally into goldfish.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A revised, high-resolution structure of psi-conotoxin Piiie (psi-Piiie), a noncompetitive inhibitor of the nicotinic acetylcholine receptor (nAChR), produced through the use of NMR and molecular modeling calculations is presented. The original structures of psi-Piiie had a relatively high degree of disorder, particularly in the conformation of the disulfide bridges. Our studies utilized (13)C-labeling of selected cysteine residues allowing the resolution of all problems of resonance overlap for the cysteine residues. The improved data were used to produce a new set of structures by a molecular modeling process incorporating relaxation matrix methods for the determination of interproton distance restraints and a combination of distance geometry and simulated annealing for structure generation. The structures produced are very well converged with the RMSD of backbone atom positions of the main body of the peptide improving from 0.73 to 0.13 A. Other indicators of correlation with the experimental data and quality of covalent geometry showed significant improvement in the new structures. The overall conformation of the peptide backbone is similar between the two determinations with the exception of the N-terminus. This difference leads to a significant effect on the predicted distribution of positive charge within psi-Piiie, a property likely to influence interpretation of future mutational studies.
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===Solution Structure of the Noncompetitive Skeletal Muscle Nicotinic Acetylcholine Receptor Antagonist Psi-conotoxin PIIIE===
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An improved solution structure for psi-conotoxin PiiiE.,Van Wagoner RM, Ireland CM Biochemistry. 2003 Jun 3;42(21):6347-52. PMID:12767215<ref>PMID:12767215</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12767215}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1jlo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12767215 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12767215}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Conus purpurascens]]
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[[1jlo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLO OCA].
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[[Category: Large Structures]]
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[[Category: Ireland CM]]
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==Reference==
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[[Category: Van Wagoner RM]]
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<ref group="xtra">PMID:012767215</ref><references group="xtra"/>
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[[Category: Ireland, C M.]]
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[[Category: Wagoner, R M.Van.]]
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[[Category: Amidated c-terminus]]
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[[Category: Multiple disulfide bond]]
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[[Category: Toxin]]
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Current revision

Solution Structure of the Noncompetitive Skeletal Muscle Nicotinic Acetylcholine Receptor Antagonist Psi-conotoxin PIIIE

PDB ID 1jlo

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