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4ntm

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==QueD soaked with sepiapterin (selenomethionine substituted protein)==
==QueD soaked with sepiapterin (selenomethionine substituted protein)==
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<StructureSection load='4ntm' size='340' side='right' caption='[[4ntm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='4ntm' size='340' side='right'caption='[[4ntm]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ntm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NTM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ntm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NTM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2K8:(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPTERIDINE-6-CARBOXYLIC+ACID'>2K8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2K8:(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPTERIDINE-6-CARBOXYLIC+ACID'>2K8</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ntm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ntm OCA], [https://pdbe.org/4ntm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ntm RCSB], [https://www.ebi.ac.uk/pdbsum/4ntm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ntm ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ntk|4ntk]], [[4ntn|4ntn]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-carboxytetrahydropterin_synthase 6-carboxytetrahydropterin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.50 4.1.2.50] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ntm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ntm OCA], [http://pdbe.org/4ntm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ntm RCSB], [http://www.ebi.ac.uk/pdbsum/4ntm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ntm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/QUED_ECOLI QUED_ECOLI]] Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP.
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[https://www.uniprot.org/uniprot/QUED_ECOLI QUED_ECOLI] Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6-carboxytetrahydropterin synthase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Bandarian, V]]
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[[Category: Large Structures]]
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[[Category: Miles, Z D]]
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[[Category: Bandarian V]]
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[[Category: S A., Roberts]]
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[[Category: Miles ZD]]
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[[Category: 6-ptp]]
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[[Category: Roberts SA]]
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[[Category: Lyase]]
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[[Category: Queuosine biosynthesis enzyme]]
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[[Category: Sepiapterin]]
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[[Category: T-fold]]
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Current revision

QueD soaked with sepiapterin (selenomethionine substituted protein)

PDB ID 4ntm

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