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4o38
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human cyclin G associated kinase (GAK)== | |
| - | + | <StructureSection load='4o38' size='340' side='right'caption='[[4o38]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4o38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O38 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o38 OCA], [https://pdbe.org/4o38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o38 RCSB], [https://www.ebi.ac.uk/pdbsum/4o38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o38 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Chaikuad A]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Eswaran J]] | ||
| + | [[Category: Fedorov O]] | ||
| + | [[Category: Hatzos-Skintges C]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: King O]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Weger A]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Zhang R]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of the human cyclin G associated kinase (GAK)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Chaikuad A | Edwards A | Eswaran J | Fedorov O | Hatzos-Skintges C | Joachimiak A | King O | Knapp S | Weger A | Weigelt J | Zhang R | Von Delft F
