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7t96
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM== | |
| - | + | <StructureSection load='7t96' size='340' side='right'caption='[[7t96]], [[Resolution|resolution]] 3.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t96]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T96 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t96 OCA], [https://pdbe.org/7t96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t96 RCSB], [https://www.ebi.ac.uk/pdbsum/7t96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t96 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Du Y]] | ||
| + | [[Category: Kobilka BK]] | ||
| + | [[Category: Wang Q]] | ||
| + | [[Category: Xu J]] | ||
Revision as of 06:28, 25 January 2023
Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM
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Categories: Homo sapiens | Large Structures | Mus musculus | Du Y | Kobilka BK | Wang Q | Xu J
