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8dwi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Molecular Mechanism of Sialic Acid Transport Mediated by Sialin== |
| - | + | <StructureSection load='8dwi' size='340' side='right'caption='[[8dwi]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8dwi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DWI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dwi OCA], [https://pdbe.org/8dwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dwi RCSB], [https://www.ebi.ac.uk/pdbsum/8dwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dwi ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/S17A5_HUMAN S17A5_HUMAN] Free sialic acid storage disease, infantile form;Salla disease;Intermediate severe Salla disease. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S17A5_HUMAN S17A5_HUMAN] Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.<ref>PMID:10581036</ref> <ref>PMID:11751519</ref> <ref>PMID:15510212</ref> <ref>PMID:21781115</ref> <ref>PMID:22778404</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hu W]] | ||
| + | [[Category: Zheng H]] | ||
Current revision
Molecular Mechanism of Sialic Acid Transport Mediated by Sialin
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