Acetyl-CoA synthase

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* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br />
* '''ACS-III''' uses pyruvate as the source of CO2 and 2 electrons to produce acetyl-CoA.<br />
* '''ACS-IV''' catabolizes CO to CO2. <br />
* '''ACS-IV''' catabolizes CO to CO2. <br />
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ACS can form a bifunctional entity with carbon monoxide dehydrogenase ('''CODH/ACS'''). CODH/ACS is part of the Woods-Ljungdahl pathway of carbon fixation using CO and methyl group to produce acetyl-CoA.
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ACS can form a bifunctional entity with [[carbon monoxide dehydrogenase]] ('''CODH/ACS'''). CODH/ACS is part of the [[Woods-Ljungdahl pathway]] of [[carbon fixation]] using CO and methyl group to produce acetyl-CoA.
== Structural highlights ==
== Structural highlights ==

Revision as of 15:50, 26 January 2023

Acetyl-CoA synthase IV subunit α with Fe4S4 center complex with glycerol (stick model) and Ni+2 ions (green) 1ru3

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References

  1. Svetlitchnyi V, Dobbek H, Meyer-Klaucke W, Meins T, Thiele B, Romer P, Huber R, Meyer O. A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):446-51. Epub 2003 Dec 29. PMID:14699043 doi:10.1073/pnas.0304262101

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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