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1jr4

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[[Image:1jr4.jpg|left|200px]]
[[Image:1jr4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jr4 |SIZE=350|CAPTION= <scene name='initialview01'>1jr4</scene>, resolution 2.63&Aring;
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The line below this paragraph, containing "STRUCTURE_1jr4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL4:N-{3-[5-(6-AMINO-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YL]-ALLYL}-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>CL4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jr4| PDB=1jr4 | SCENE= }}
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|RELATEDENTRY=[[1vid|1VID]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr4 OCA], [http://www.ebi.ac.uk/pdbsum/1jr4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jr4 RCSB]</span>
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}}
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'''CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX'''
'''CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX'''
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[[Category: Ruf, A.]]
[[Category: Ruf, A.]]
[[Category: Stihle, M.]]
[[Category: Stihle, M.]]
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[[Category: bisubstrate inhibitor]]
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[[Category: Bisubstrate inhibitor]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: neurotransmitter degradation]]
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[[Category: Neurotransmitter degradation]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:43:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:49 2008''
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Revision as of 18:43, 2 May 2008

Image:1jr4.jpg

Template:STRUCTURE 1jr4

CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX


About this Structure

1JR4 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. , Lerner C, Ruf A, Gramlich V, Masjost B, Zurcher G, Jakob-Roetne R, Borroni E, Diederich F, Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. PMID:12404486 Page seeded by OCA on Fri May 2 21:43:10 2008

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