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1jro

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[[Image:1jro.gif|left|200px]]
[[Image:1jro.gif|left|200px]]
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{{Structure
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|PDB= 1jro |SIZE=350|CAPTION= <scene name='initialview01'>1jro</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1jro", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MOS:DIOXOTHIOMOLYBDENUM(VI)+ION'>MOS</scene>, <scene name='pdbligand=MPN:PHOSPHORIC+ACID+MONO-(2-AMINO-4-OXO-5,6-DITHIOXO-1,5,6,7,8A,9,10,10A-OCTAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)+ESTER'>MPN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Xanthine_dehydrogenase Xanthine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.4 1.17.1.4] </span>
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{{STRUCTURE_1jro| PDB=1jro | SCENE= }}
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|RELATEDENTRY=[[1jrp|1JRP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jro OCA], [http://www.ebi.ac.uk/pdbsum/1jro PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jro RCSB]</span>
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'''Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus'''
'''Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus'''
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[[Category: Theis, K.]]
[[Category: Theis, K.]]
[[Category: Truglio, J J.]]
[[Category: Truglio, J J.]]
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[[Category: partial beta-barrel]]
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[[Category: Partial beta-barrel]]
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[[Category: xdh]]
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[[Category: Xdh]]
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[[Category: xo]]
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[[Category: Xo]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:46:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:01 2008''
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Revision as of 18:46, 2 May 2008

Image:1jro.gif

Template:STRUCTURE 1jro

Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus


Overview

Xanthine dehydrogenase (XDH), a complex molybdo/iron-sulfur/flavoprotein, catalyzes the oxidation of hypoxanthine to xanthine followed by oxidation of xanthine to uric acid with concomitant reduction of NAD+. The 2.7 A resolution structure of Rhodobacter capsulatus XDH reveals that the bacterial and bovine XDH have highly similar folds despite differences in subunit composition. The NAD+ binding pocket of the bacterial XDH resembles that of the dehydrogenase form of the bovine enzyme rather than that of the oxidase form, which reduces O(2) instead of NAD+. The drug allopurinol is used to treat XDH-catalyzed uric acid build-up occurring in gout or during cancer chemotherapy. As a hypoxanthine analog, it is oxidized to alloxanthine, which cannot be further oxidized but acts as a tight binding inhibitor of XDH. The 3.0 A resolution structure of the XDH-alloxanthine complex shows direct coordination of alloxanthine to the molybdenum via a nitrogen atom. These results provide a starting point for the rational design of new XDH inhibitors.

About this Structure

1JRO is a Protein complex structure of sequences from Rhodobacter capsulatus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus., Truglio JJ, Theis K, Leimkuhler S, Rappa R, Rajagopalan KV, Kisker C, Structure. 2002 Jan;10(1):115-25. PMID:11796116 Page seeded by OCA on Fri May 2 21:46:09 2008

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