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3us4

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[[Image:3us4.jpg|left|200px]]
 
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==Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution==
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The line below this paragraph, containing "STRUCTURE_3us4", creates the "Structure Box" on the page.
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<StructureSection load='3us4' size='340' side='right'caption='[[3us4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3us4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3US4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3US4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3us4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3us4 OCA], [https://pdbe.org/3us4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3us4 RCSB], [https://www.ebi.ac.uk/pdbsum/3us4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3us4 ProSAT]</span></td></tr>
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{{STRUCTURE_3us4| PDB=3us4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MATK_HUMAN MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.<ref>PMID:9171348</ref>
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===Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution===
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==See Also==
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*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3us4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3US4 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Biology, Partnership for T-Cell.]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Jcsg]]
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[[Category: Joint center for structural genomic]]
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[[Category: Partnership for t-cell biology]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Sh2 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution

PDB ID 3us4

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