4p8h
From Proteopedia
(Difference between revisions)
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<StructureSection load='4p8h' size='340' side='right'caption='[[4p8h]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4p8h' size='340' side='right'caption='[[4p8h]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4p8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8H OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4p8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P8H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O95:{(4S)-2-[7-(HYDROXYAMINO)-6-METHYL-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]-4,5-DIHYDRO-1,3-OXAZOL-4-YL}(PYRROLIDIN-1-YL)METHANONE'>O95</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O95:{(4S)-2-[7-(HYDROXYAMINO)-6-METHYL-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]-4,5-DIHYDRO-1,3-OXAZOL-4-YL}(PYRROLIDIN-1-YL)METHANONE'>O95</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8h OCA], [https://pdbe.org/4p8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p8h RCSB], [https://www.ebi.ac.uk/pdbsum/4p8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8h ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: | + | [[Category: Cole ST]] |
| - | [[Category: | + | [[Category: Neres J]] |
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Revision as of 12:47, 1 February 2023
Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a
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