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4pin

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==Ergothioneine-biosynthetic methyltransferase EgtD in complex with N,N-dimethylhistidine==
==Ergothioneine-biosynthetic methyltransferase EgtD in complex with N,N-dimethylhistidine==
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<StructureSection load='4pin' size='340' side='right' caption='[[4pin]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4pin' size='340' side='right'caption='[[4pin]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PIN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVI:N,N-DIMETHYL-L-HISTIDINE'>AVI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AVI:N,N-DIMETHYL-L-HISTIDINE'>AVI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pim|4pim]], [[4pio|4pio]], [[4pip|4pip]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pin OCA], [https://pdbe.org/4pin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pin RCSB], [https://www.ebi.ac.uk/pdbsum/4pin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pin ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">egtD, MSMEG_6247, MSMEI_6086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1772 "Bacillus smegmatis" Trevisan 1889])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-histidine_N(alpha)-methyltransferase L-histidine N(alpha)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.44 2.1.1.44] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pin OCA], [http://pdbe.org/4pin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pin RCSB], [http://www.ebi.ac.uk/pdbsum/4pin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pin ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EGTD_MYCS2 EGTD_MYCS2]] Catalyzes the methylations of histidine to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine). Histidine and alpha-N,N-dimethylhistidine are preferred substrates.<ref>PMID:20420449</ref>
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[https://www.uniprot.org/uniprot/EGTD_MYCS2 EGTD_MYCS2] Catalyzes the methylations of histidine to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine). Histidine and alpha-N,N-dimethylhistidine are preferred substrates.<ref>PMID:20420449</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus smegmatis trevisan 1889]]
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[[Category: Large Structures]]
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[[Category: Blankenfeldt, W]]
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[[Category: Mycolicibacterium smegmatis]]
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[[Category: Seebeck, F P]]
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[[Category: Blankenfeldt W]]
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[[Category: Vit, A]]
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[[Category: Seebeck FP]]
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[[Category: Ergothioneine]]
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[[Category: Vit A]]
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[[Category: Histidine betaine]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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Revision as of 13:07, 1 February 2023

Ergothioneine-biosynthetic methyltransferase EgtD in complex with N,N-dimethylhistidine

PDB ID 4pin

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