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4piv

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<StructureSection load='4piv' size='340' side='right'caption='[[4piv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4piv' size='340' side='right'caption='[[4piv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4piv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4piv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PIV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W4:4-[4-(1-BENZOFURAN-5-YL)PHENYL]-5-{[(3S)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>2W4</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W4:4-[4-(1-BENZOFURAN-5-YL)PHENYL]-5-{[(3S)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>2W4</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FASN, FAS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4piv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4piv OCA], [https://pdbe.org/4piv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4piv RCSB], [https://www.ebi.ac.uk/pdbsum/4piv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4piv ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4piv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4piv OCA], [http://pdbe.org/4piv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4piv RCSB], [http://www.ebi.ac.uk/pdbsum/4piv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4piv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
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[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fatty-acid synthase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brown, K K]]
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[[Category: Brown KK]]
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[[Category: Hardwicke, M A]]
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[[Category: Hardwicke MA]]
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[[Category: Parrish, C A]]
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[[Category: Parrish CA]]
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[[Category: Wang, L]]
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[[Category: Wang L]]
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[[Category: Williams, S P]]
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[[Category: Williams SP]]
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[[Category: Fatty acid synthase]]
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[[Category: Human fa]]
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[[Category: Keto-reductase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 13:07, 1 February 2023

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069

PDB ID 4piv

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