Ecotin

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{{STRUCTURE_1p0s| PDB=1p0s | SIZE=400| SCENE= |right|CAPTION=E. coli ecotin complex with factor Xa, γ-carboxy-glutamic acid, Mg+2 and Na+ ions, [[1p0s]] }}
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<StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/2' caption='The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) [[1id5]]'>
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'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.
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'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref>
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{{TOC limit|limit=2}}
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<scene name='46/465444/Cv/7'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/8'>thrombin heavy and light chains</scene>.
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<scene name='46/465444/Cv/9'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres.
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</StructureSection>
== 3D Structures of Ecotin ==
== 3D Structures of Ecotin ==
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''Updated November 2011''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
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*Ecotin
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[[1ifg]] - ECO (mutant)
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Ecotin complex with protein
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**[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
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**[[1ifg]] - ECO (mutant)
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[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]] – ECO (mutant) + anionic trypsin (mutant) <br />
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*Ecotin complex with protein
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[[1azz]] – ECO + collagenase<br />
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[[1id5]] - ECO (mutant) + thrombin<br />
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[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
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[[1p0s]] - ECO (mutant) + factor Xa<br />
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[[1xx9]] - ECO (mutant) + factor Xi<br />
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[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
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[[1fi8]] - ECO (mutant) + granzyme B
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**[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]], [[4niy]] – ECO (mutant) + anionic trypsin (mutant) <br />
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**[[1azz]] – ECO + collagenase<br />
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**[[1id5]] - ECO (mutant) + thrombin<br />
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**[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
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**[[1p0s]] - ECO (mutant) + factor Xa<br />
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**[[1xx9]] - ECO (mutant) + factor Xi<br />
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**[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
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**[[1fi8]] - ECO (mutant) + granzyme B<br />
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**[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
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**[[7cbk]] – ECO + elastase<br />
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**[[7pqo]] – ECO (mutant) + MASP-1<br />
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**[[7pqn]] – ECO + MASP-2<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) 1id5

Drag the structure with the mouse to rotate

3D Structures of Ecotin

Updated on 08-February-2023

References

  1. ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
  2. ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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