Ecotin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:53, 8 February 2023) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1id5| PDB=1id5 | SIZE=400| SCENE= |right|CAPTION=A monomer of the dimeric E. coli ecotin (gold) complex with thrombin heavy chain (pink) and light chain (aqua), protease inhibitor and Ca+2 ion [[1id5]] }}
+
<StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/2' caption='The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) [[1id5]]'>
-
'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.
+
'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref>
-
{{TOC limit|limit=2}}
+
<scene name='46/465444/Cv/7'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/8'>thrombin heavy and light chains</scene>.
 +
<scene name='46/465444/Cv/9'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres.
 +
</StructureSection>
== 3D Structures of Ecotin ==
== 3D Structures of Ecotin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
+
*Ecotin
-
[[1ifg]] - ECO (mutant)
+
-
Ecotin complex with protein
+
**[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br />
 +
**[[1ifg]] - ECO (mutant)
-
[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]] – ECO (mutant) + anionic trypsin (mutant) <br />
+
*Ecotin complex with protein
-
[[1azz]] – ECO + collagenase<br />
+
-
[[1id5]] - ECO (mutant) + thrombin<br />
+
-
[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
+
-
[[1p0s]] - ECO (mutant) + factor Xa<br />
+
-
[[1xx9]] - ECO (mutant) + factor Xi<br />
+
-
[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
+
-
[[1fi8]] - ECO (mutant) + granzyme B
+
 +
**[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]], [[4niy]] – ECO (mutant) + anionic trypsin (mutant) <br />
 +
**[[1azz]] – ECO + collagenase<br />
 +
**[[1id5]] - ECO (mutant) + thrombin<br />
 +
**[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br />
 +
**[[1p0s]] - ECO (mutant) + factor Xa<br />
 +
**[[1xx9]] - ECO (mutant) + factor Xi<br />
 +
**[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br />
 +
**[[1fi8]] - ECO (mutant) + granzyme B<br />
 +
**[[4iw4]] – ECO + mannan-binding lectin serine protease<br />
 +
**[[7cbk]] – ECO + elastase<br />
 +
**[[7pqo]] – ECO (mutant) + MASP-1<br />
 +
**[[7pqn]] – ECO + MASP-2<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) 1id5

Drag the structure with the mouse to rotate

3D Structures of Ecotin

Updated on 08-February-2023

References

  1. ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
  2. ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Ecotin"
Personal tools