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End-binding protein

From Proteopedia

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'''End-binding protein''' (EB) regulates microtubules dynamics, promotes colony formation and enhances tumor growth. EB is part of the proteins which accumulate at the growing microtubule plus end. During mitosis the EB associates with centrosome and spindle microtubules. EB is involved in the regulation of chromosome stability and microtubule structure. The C terminal domains of EB1 and EB3 are involved in dimer formation. The CH (Calponin Homology) domain is an actin-binding domain<ref>PMID:11470413</ref>.
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'''End-binding protein''' or '''telomere-binding protein''' or '''microtubule-associated protein RP/EB family member''' (EB) regulates microtubules dynamics, promotes colony formation and enhances tumor growth. EB is part of the proteins which accumulate at the growing microtubule plus end. During mitosis the EB associates with centrosome and spindle microtubules. EB is involved in the regulation of chromosome stability and microtubule structure. The C terminal domains of EB1 and EB3 are involved in dimer formation. The CH (Calponin Homology) domain is an actin-binding domain<ref>PMID:11470413</ref>.
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**[[1txq]], [[2hkq]], [[2hl5]] – hEB1 C terminal + dynactin<br />
**[[1txq]], [[2hkq]], [[2hl5]] – hEB1 C terminal + dynactin<br />
**[[3gjo]] – hEB1 C terminal + dystonin<br />
**[[3gjo]] – hEB1 C terminal + dystonin<br />
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**[[2qjz]] – hEB1 CH domain <br />
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**[[2qjz]] – hEB1 CH domain 12-133<br />
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**[[1v5k]] – EB1 CH domain (mutant) – mouse - NMR<br />
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**[[5n74]] – hEB1 + KAR9 <br />
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**[[1v5k]] – mEB1 CH domain (mutant) – mouse - NMR<br />
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**[[6evi]] – mEB1 C-terminal 191-260 - NMR<br />
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**[[6evj]] – mEB1 C-terminal + modulator - NMR<br />
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**[[7olg]] – mEB1 C-terminal + peptide - NMR<br />
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**[[1k8g]], [[1kix]], [[1otc]], [[1ph1]], [[1ph2]], [[1ph3]], [[1ph4]], [[1ph5]], [[1ph6]], [[1ph7]], [[1ph8]], [[1ph9]], [[1phj]] – EB1 alpha+beta subunits + DNA – ''Sterkiella nova'' <br />
*End-binding protein 3
*End-binding protein 3
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**[[3co1]] – hEB3 CH domain <br />
**[[3co1]] – hEB3 CH domain <br />
**[[1wyo]] – hEB3 CH domain - NMR<br />
**[[1wyo]] – hEB3 CH domain - NMR<br />
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**[[3jak]], [[7sj9]] – hEB3 + tubulin – Cryo EM <br />
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**[[3jal]] – hEB3 + tubulin + GMPCPP – Cryo EM <br />
*End-binding protein 1+3
*End-binding protein 1+3

Current revision

Human end-binding protein 1 C terminal (grey) complex with dynactin-1 CAP-GLY domain (green) (PDB code 2hkq)

Drag the structure with the mouse to rotate

3D Structures of end-binding protein

Updated on 14-February-2023

References

  1. ↑ Nakamura M, Zhou XZ, Lu KP. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr Biol. 2001 Jul 10;11(13):1062-7. PMID:11470413

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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