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5om9

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Current revision (10:16, 15 February 2023) (edit) (undo)
 
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==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor==
==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor==
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<StructureSection load='5om9' size='340' side='right' caption='[[5om9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5om9' size='340' side='right'caption='[[5om9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5om9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OM9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5om9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uf4 4uf4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OM9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O2S:(2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic+acid'>O2S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O2S:(2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic+acid'>O2S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPA1, CPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5om9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5om9 OCA], [https://pdbe.org/5om9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5om9 RCSB], [https://www.ebi.ac.uk/pdbsum/5om9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5om9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5om9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5om9 OCA], [http://pdbe.org/5om9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5om9 RCSB], [http://www.ebi.ac.uk/pdbsum/5om9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5om9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
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[https://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5om9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5om9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carboxypeptidase A]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Aviles, F X]]
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[[Category: Aviles FX]]
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[[Category: Covaleda, G]]
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[[Category: Covaleda G]]
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[[Category: Fernandez, D]]
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[[Category: Fernandez D]]
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[[Category: Gallego, P]]
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[[Category: Gallego P]]
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[[Category: Granados, C]]
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[[Category: Granados C]]
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[[Category: Pallares, I]]
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[[Category: Pallares I]]
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[[Category: Reverter, D]]
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[[Category: Reverter D]]
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[[Category: Vendrell, J]]
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[[Category: Vendrell J]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor

PDB ID 5om9

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