1jwc

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[[Image:1jwc.gif|left|200px]]
[[Image:1jwc.gif|left|200px]]
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{{Structure
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|PDB= 1jwc |SIZE=350|CAPTION= <scene name='initialview01'>1jwc</scene>
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The line below this paragraph, containing "STRUCTURE_1jwc", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1jwc| PDB=1jwc | SCENE= }}
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|RELATEDENTRY=[[1ju7|1JU7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwc OCA], [http://www.ebi.ac.uk/pdbsum/1jwc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jwc RCSB]</span>
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'''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN'''
'''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN'''
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==About this Structure==
==About this Structure==
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1JWC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA].
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1JWC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA].
==Reference==
==Reference==
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[[Category: Nikonowicz, E P.]]
[[Category: Nikonowicz, E P.]]
[[Category: 3' stack]]
[[Category: 3' stack]]
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[[Category: hairpin]]
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[[Category: Hairpin]]
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[[Category: tetraloop]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:39:58 2008''
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Revision as of 19:00, 2 May 2008

Image:1jwc.gif

Template:STRUCTURE 1jwc

NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN


Overview

The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism and regulation. We have determined the structure of the 26-nt sequence by multidimensional NMR spectroscopy. There is a 16-nt stem-loop motif, with a conserved 6-bp stem and a 4-nt loop. The loop is closed by a conserved U.A base pair that terminates the canonical A-form stem. The pyrimidine-rich 4-nt loop, UUUC, is well organized with the three uridines stacking on the helix, and the fourth base extending across the major groove into the solvent. The flanking nucleotides at the base of the hairpin stem do not assume a unique conformation, despite the fact that the 5' flanking nucleotides are a critical component of the SLBP binding site.

About this Structure

1JWC is a Single protein structure. Full crystallographic information is available from OCA.

Reference

NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:11871662 Page seeded by OCA on Fri May 2 22:00:18 2008

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