1jym
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1jym.gif|left|200px]] | [[Image:1jym.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1jym", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_1jym| PDB=1jym | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Crystals of Peptide Deformylase from Plasmodium falciparum with Ten Subunits per Asymmetric Unit Reveal Critical Characteristics of the Active Site for Drug Design''' | '''Crystals of Peptide Deformylase from Plasmodium falciparum with Ten Subunits per Asymmetric Unit Reveal Critical Characteristics of the Active Site for Drug Design''' | ||
| Line 34: | Line 31: | ||
[[Category: Srivathsan, S.]] | [[Category: Srivathsan, S.]] | ||
[[Category: Turley, S.]] | [[Category: Turley, S.]] | ||
| - | [[Category: | + | [[Category: Deformylation]] |
| - | [[Category: | + | [[Category: Malaria]] |
| - | [[Category: | + | [[Category: Metalloenzyme]] |
| - | [[Category: | + | [[Category: Pdf]] |
| - | [[Category: | + | [[Category: Plasmodium]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:04:55 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:04, 2 May 2008
Crystals of Peptide Deformylase from Plasmodium falciparum with Ten Subunits per Asymmetric Unit Reveal Critical Characteristics of the Active Site for Drug Design
Overview
Peptide deformylase catalyzes the deformylation reaction of the amino terminal fMet residue of newly synthesized proteins in bacteria, and most likely in Plasmodium falciparum, and has therefore been identified as a potential antibacterial and antimalarial drug target. The structure of P. falciparum peptide deformylase, determined at 2.8 A resolution with ten subunits per asymmetric unit, is similar to the bacterial enzyme with the residues involved in catalysis, the position of the bound metal ion, and a catalytically important water structurally conserved between the two enzymes. However, critical differences in the substrate binding region explain the poor affinity of E. coli deformylase inhibitors and substrates toward the Plasmodium enzyme. The Plasmodium structure serves as a guide for designing novel antimalarials.
About this Structure
1JYM is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design., Kumar A, Nguyen KT, Srivathsan S, Ornstein B, Turley S, Hirsh I, Pei D, Hol WG, Structure. 2002 Mar;10(3):357-67. PMID:12005434 Page seeded by OCA on Fri May 2 22:04:55 2008
