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7u1t
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7u1t is ON HOLD until Feb 22 2024 Authors: Mei, Y., Lieberman, P. Description: EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry eleme...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry element== | |
| - | + | <StructureSection load='7u1t' size='340' side='right'caption='[[7u1t]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7u1t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U1T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u1t OCA], [https://pdbe.org/7u1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u1t RCSB], [https://www.ebi.ac.uk/pdbsum/7u1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u1t ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Lieberman | + | == Function == |
| - | [[Category: Mei | + | [https://www.uniprot.org/uniprot/EBNA1_EBVB9 EBNA1_EBVB9] Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.<ref>PMID:15808506</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human herpesvirus 4 strain B95-8]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lieberman P]] | ||
| + | [[Category: Mei Y]] | ||
Current revision
EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry element
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