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2m1k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Interaction of Human S100A6 (C3S) with V domain of Receptor for Advanced Glycation End products (RAGE)== | |
| + | <StructureSection load='2m1k' size='340' side='right'caption='[[2m1k]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m1k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1K FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1k OCA], [https://pdbe.org/2m1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1k RCSB], [https://www.ebi.ac.uk/pdbsum/2m1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S10A6_HUMAN S10A6_HUMAN] May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | S100A6 is involved in several vital biological functions, such as calcium sensing and cell proliferation. It is a homodimeric protein that belongs to the S100 protein family. The receptor for advanced glycation end products (RAGE) has been shown to play a role in the progression of various disease conditions, such as diabetes and immune/inflammatory disorders. Information regarding the association of RAGE with S100 proteins at a molecular level is useful to understand the diversity of the RAGE signaling pathways. In this report, biomolecular NMR techniques were utilized for the resonance assignment of the C3S mutation in human S100A6 and characterizing its interaction with the RAGE V domain. Further binding affinity between S100A6m and the RAGE V domain was determined by isothermal titration calorimetric studies. HADDOCK was used to generate a heterotetramer model of the S100A6m-RAGE V domain complex. This model provides an important insights into the S100-RAGE cellular signaling pathway. | ||
| - | + | Interaction of the S100A6 mutant (C3S) with the V domain of the receptor for advanced glycation end products (RAGE).,Mohan SK, Gupta AA, Yu C Biochem Biophys Res Commun. 2013 May 3;434(2):328-33. doi:, 10.1016/j.bbrc.2013.03.049. Epub 2013 Mar 26. PMID:23537648<ref>PMID:23537648</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2m1k" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[S100 proteins 3D structures|S100 proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gupta AA]] | ||
| + | [[Category: Yu C]] | ||
Current revision
Interaction of Human S100A6 (C3S) with V domain of Receptor for Advanced Glycation End products (RAGE)
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