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4r08

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==Crystal structure of human TLR8 in complex with ssRNA40==
==Crystal structure of human TLR8 in complex with ssRNA40==
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<StructureSection load='4r08' size='340' side='right' caption='[[4r08]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4r08' size='340' side='right'caption='[[4r08]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R08 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r08]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R08 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UCG:3-O-[(R)-{[(2R,3AR,4R,6R,6AR)-6-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-2-HYDROXY-2-OXIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]METHOXY}(HYDROXY)PHOSPHORYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UCG</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UCG:3-O-[(R)-{[(2R,3AR,4R,6R,6AR)-6-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-2-HYDROXY-2-OXIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]METHOXY}(HYDROXY)PHOSPHORYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UCG</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r07|4r07]], [[4r09|4r09]], [[4r0a|4r0a]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r08 OCA], [https://pdbe.org/4r08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r08 RCSB], [https://www.ebi.ac.uk/pdbsum/4r08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r08 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r08 RCSB], [http://www.ebi.ac.uk/pdbsum/4r08 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
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[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4r08" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ohto, U]]
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[[Category: Homo sapiens]]
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[[Category: Shimizu, T]]
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[[Category: Large Structures]]
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[[Category: Tanji, H]]
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[[Category: Ohto U]]
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[[Category: Antitumor drug binding]]
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[[Category: Shimizu T]]
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[[Category: Antiviral binding]]
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[[Category: Tanji H]]
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[[Category: Glycosylation]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Leucine rich repeat]]
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[[Category: Rna binding]]
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[[Category: Rna receptor]]
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[[Category: Rna recognition]]
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Current revision

Crystal structure of human TLR8 in complex with ssRNA40

PDB ID 4r08

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