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Epidermal growth factor

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{{STRUCTURE_2jl9| PDB=1jl9 | SIZE=400| SCENE= |right|CAPTION=Human epidermal growth factor, [[1jl9]] }}
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<StructureSection load='1jl9' size='350' side='right' scene='47/479230/Cv/1' caption='Dimer of the monomeric human epidermal growth factor (PDB code [[1jl9]]) '>
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== Function ==
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'''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor (EGFR).
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EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.
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All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds. Some details on EGF exon in [[EGF1]].
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{{TOC limit|limit=2}}
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'''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor ([[Epidermal Growth Factor Receptor|EGFR]]). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.<ref>PMID:2186024</ref> Some details<br />
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on EGF exon in [[EGF1]]<br />
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on Gla domain in [[Gla domain]]<br />
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[[Pre-prozymogen]].
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== Relevance ==
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EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination.
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== Structural highlights ==
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All EGF family proteins contain a conserved amino acid sequence which includes <scene name='47/479230/Cv/3'>3 disulfide bonds</scene> (PDB code [[1jl9]]).<ref>PMID:11438527</ref>
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</StructureSection>
==3D structures of epidermal growth factor==
==3D structures of epidermal growth factor==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*EGF
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[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br />
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**[[1jl9]] – hEGF<br/ >
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[[1a3p]] – mEGF (mutant) – NMR<br />
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**[[2kv4]] – hEGF - NMR<br/ >
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[[1jl9]] – hEGF<br/ >
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**[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR<br />
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[[2kv4]] – hEGF - NMR<br/ >
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**[[1ivo]], [[3njp]] – hEGF 1-53 + EGFR<br />
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[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR
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**[[1nql]] – hEGF 971-1023 + EGFR<br />
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**[[7syd]], [[7sye]], [[7sz0]], [[7sz1]], [[8hgs]] - hEGF 971-1023 + EGFR – Cryo EM<br />
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**[[7om4]] - hEGF 971-1023 + EGFR + nanobody<br />
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**[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br />
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**[[1a3p]] – mEGF (mutant) – NMR<br />
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===Heparin-binding EGF-like growth factor===
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*Heparin-binding EGF-like growth factor
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[[1xdt]] – hHB-EGF extracellular domain + diphtheria toxin
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**[[1xdt]] – hHB-EGF extracellular domain + diphtheria toxin
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===EGF-like Cripto protein===
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*EGF-like Cripto protein
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[[2j5h]] – mCR-EGF residues 96-134 - NMR
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**[[2j5h]] – mCR-EGF residues 96-134 - NMR
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Dimer of the monomeric human epidermal growth factor (PDB code 1jl9)

Drag the structure with the mouse to rotate

3D structures of epidermal growth factor

Updated on 23-February-2023

References

  1. ↑ Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem. 1990 May 15;265(14):7709-12. PMID:2186024
  2. ↑ Lu HS, Chai JJ, Li M, Huang BR, He CH, Bi RC. Crystal structure of human epidermal growth factor and its dimerization. J Biol Chem. 2001 Sep 14;276(37):34913-7. Epub 2001 Jul 3. PMID:11438527 doi:10.1074/jbc.M102874200

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Michal Harel, Alexander Berchansky

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