Epidermal growth factor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='1jl9' size='350' side='right' scene='47/479230/Cv/1' caption='Dimer of the monomeric human epidermal growth factor (PDB code [[1jl9]]) '> |
== Function == | == Function == | ||
| - | '''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor ([[Epidermal Growth Factor Receptor|EGFR]]). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. | + | '''Epidermal growth factor''' (EGF) plays a role in cell growth. It binds to its receptor ([[Epidermal Growth Factor Receptor|EGFR]]). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.<ref>PMID:2186024</ref> Some details<br /> |
| + | on EGF exon in [[EGF1]]<br /> | ||
| + | on Gla domain in [[Gla domain]]<br /> | ||
| + | [[Pre-prozymogen]]. | ||
== Relevance == | == Relevance == | ||
EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination. | EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination. | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | All EGF family proteins contain a conserved amino acid sequence which includes <scene name='47/479230/Cv/3'>3 disulfide bonds</scene> (PDB code [[1jl9]]).<ref>PMID:11438527</ref> | ||
</StructureSection> | </StructureSection> | ||
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*EGF | *EGF | ||
| - | **[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br /> | ||
| - | **[[1a3p]] – mEGF (mutant) – NMR<br /> | ||
**[[1jl9]] – hEGF<br/ > | **[[1jl9]] – hEGF<br/ > | ||
**[[2kv4]] – hEGF - NMR<br/ > | **[[2kv4]] – hEGF - NMR<br/ > | ||
**[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR<br /> | **[[1gk5]], [[1p9j]] – hEGF/transforming growth factor alpha - NMR<br /> | ||
| - | **[[1ivo]], [[1nql]], [[ | + | **[[1ivo]], [[3njp]] – hEGF 1-53 + EGFR<br /> |
| + | **[[1nql]] – hEGF 971-1023 + EGFR<br /> | ||
| + | **[[7syd]], [[7sye]], [[7sz0]], [[7sz1]], [[8hgs]] - hEGF 971-1023 + EGFR – Cryo EM<br /> | ||
| + | **[[7om4]] - hEGF 971-1023 + EGFR + nanobody<br /> | ||
| + | **[[1egf]], [[1epg]], [[1eph]], [[1epi]], [[1epj]], [[3egf]] – mEGF – mouse – NMR<br /> | ||
| + | **[[1a3p]] – mEGF (mutant) – NMR<br /> | ||
*Heparin-binding EGF-like growth factor | *Heparin-binding EGF-like growth factor | ||
Current revision
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3D structures of epidermal growth factor
Updated on 23-February-2023
References
- ↑ Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem. 1990 May 15;265(14):7709-12. PMID:2186024
- ↑ Lu HS, Chai JJ, Li M, Huang BR, He CH, Bi RC. Crystal structure of human epidermal growth factor and its dimerization. J Biol Chem. 2001 Sep 14;276(37):34913-7. Epub 2001 Jul 3. PMID:11438527 doi:10.1074/jbc.M102874200
