Factor VIII

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Current revision (08:56, 27 February 2023) (edit) (undo)
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br />
+
[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br />
-
[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />
+
[[6mf0]] – h/pFVIII<br />
 +
[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
-
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
+
[[7k66]], [[7kbt]] – h/pFVIII + antibody<br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
-
[[4pt6]] - hFVIII discoidin domain <br />
+
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
 +
[[3j2s]] - hFVIII light chain 1710-2356<br />
 +
[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br />
 +
[[7kwo]] – hFVIII + VWF-XTEN<br />
 +
[[4mo3]] - pFVIII light chain C2 domain – pig<br />
 +
[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
-
[[3j2s]] - hFVIII light chain<br />
 
-
[[5k8d]] - hFVIII heavy chain + light chain residus 104-329<br />
 
-
[[4mo3]] - FVIII light chain C2 domain – pig<br />
 
== References ==
== References ==
<references/>
<references/>

Current revision

Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 27-February-2023

2r7e, 3cdz, 3j2q, 4bdv, 6mf2 – hFVIII 19-760+1582-2351 – human
6mf0 – h/pFVIII
3hnb, 3hny, 3hob, 4pt6 – hFVIII light chain C2 domain 2189-2347
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
7k66, 7kbt – h/pFVIII + antibody
4xzu - hFVIII light chain C2 domain + monoclonal Fab
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
3j2s - hFVIII light chain 1710-2356
5k8d - hFVIII heavy chain + light chain residues 104-329
7kwo – hFVIII + VWF-XTEN
4mo3 - pFVIII light chain C2 domain – pig
7s0p - pFVIII light chain C2 domain + phosphatidylserine
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse

References

  1. ↑ White GC 2nd, Shoemaker CB. Factor VIII gene and hemophilia A. Blood. 1989 Jan;73(1):1-12. PMID:2491949
  2. ↑ Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL. The tertiary structure and domain organization of coagulation factor VIII. Blood. 2008 Feb 1;111(3):1240-7. Epub 2007 Oct 26. PMID:17965321 doi:10.1182/blood-2007-08-109918

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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