1k1z

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[[Image:1k1z.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1z OCA], [http://www.ebi.ac.uk/pdbsum/1k1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k1z RCSB]</span>
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'''Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav'''
'''Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav'''
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[[Category: Ogura, K.]]
[[Category: Ogura, K.]]
[[Category: Yuzawa, S.]]
[[Category: Yuzawa, S.]]
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[[Category: proto-oncogene]]
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[[Category: Proto-oncogene]]
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[[Category: sh3]]
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[[Category: Sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:12 2008''
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Revision as of 19:12, 2 May 2008

Image:1k1z.gif

Template:STRUCTURE 1k1z

Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav


Overview

The three-dimensional structure of the N-terminal SH3 domain (residues 583-660) of murine Vav, which contains a tetra-proline sequence (Pro 607-Pro 610), was determined by NMR. The solution structure of the SH3 domain shows a typical SH3 fold, but it exists in two conformations due to cis-trans isomerization at the Gly614-Pro615 bond. The NMR structure of the P615G mutant, where Pro615 is replaced by glycine, reveals that the tetra-proline region is inserted into the RT-loop and binds to its own SH3 structure. The C-terminal SH3 domain of Grb2 specifically binds to the trans form of the N-terminal SH3 domain of Vav. The surface of Vav N-terminal SH3 which binds to Grb2 C-terminal SH3 was elucidated by chemical shift mapping experiments using NMR. The surface does not involve the tetra-proline region but involves the region comprising the n-src loop, the N-terminal and the C-terminal regions. This surface is located opposite to the tetra-proline containing region, consistent with that of our previous mutagenesis studies.

About this Structure

1K1Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain., Ogura K, Nagata K, Horiuchi M, Ebisui E, Hasuda T, Yuzawa S, Nishida M, Hatanaka H, Inagaki F, J Biomol NMR. 2002 Jan;22(1):37-46. PMID:11885979 Page seeded by OCA on Fri May 2 22:12:05 2008

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