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4rak

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<StructureSection load='4rak' size='340' side='right'caption='[[4rak]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
<StructureSection load='4rak' size='340' side='right'caption='[[4rak]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=652:2-{2-[2-(2-CHLOROPHENYL)PROPAN-2-YL]-1-[3-(METHYLSULFONYL)BIPHENYL-4-YL]-1H-IMIDAZOL-4-YL}PROPAN-2-OL'>652</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=652:2-{2-[2-(2-CHLOROPHENYL)PROPAN-2-YL]-1-[3-(METHYLSULFONYL)BIPHENYL-4-YL]-1H-IMIDAZOL-4-YL}PROPAN-2-OL'>652</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1H2, LXRB, NER, UNR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rak OCA], [https://pdbe.org/4rak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rak RCSB], [https://www.ebi.ac.uk/pdbsum/4rak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rak ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rak OCA], [http://pdbe.org/4rak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rak RCSB], [http://www.ebi.ac.uk/pdbsum/4rak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rak ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nanao, M]]
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[[Category: Nanao M]]
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[[Category: Ligand binding domain]]
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[[Category: Lxr-b]]
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[[Category: Lxrb]]
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[[Category: Ner]]
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[[Category: Ner-i]]
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[[Category: Nhr]]
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[[Category: Nr1h2]]
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[[Category: Nuclear hormone receptor]]
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[[Category: Rip15]]
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[[Category: Rxr]]
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[[Category: Transcription-agonist complex]]
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[[Category: Unr]]
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Revision as of 06:47, 2 March 2023

Crystal structure of nuclear receptor subfamily 1, group h, member 2 (lxrb) complexed with partial agonist

PDB ID 4rak

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