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Flavin reductase

From Proteopedia

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== Structural insights ==
== Structural insights ==
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The <scene name='49/490853/Cv/3'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
+
The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
</StructureSection>
</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*NADPH-dependent Flavin reductase
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*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
-
**[[1qfj]] – FR – ''Escherichia coli''<br />
+
**[[1hdo]], [[7er6]] - hFR + NADP - human<br />
-
**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
+
**[[6opl]] – hFR (mutant) + NADP <br />
-
**[[2bkj]] - VhFR + NAD + FMN<br />
+
-
**[[1hdo]] - hFR + NADP - human<br />
+
**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
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**[[5ooh]] – hFR + NADP + erythrosine<br />
**[[5ooh]] – hFR + NADP + erythrosine<br />
**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
 +
**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
**[[5cho]] - FR + FAD – uncultured bacteria<br />
**[[5cho]] - FR + FAD – uncultured bacteria<br />
 +
**[[1qfj]] – FR – ''Escherichia coli''<br />
 +
**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
 +
**[[2bkj]] - VhFR + NAD + FMN<br />
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*NADPH-dependent Flavin reductase
+
*NADH-dependent Flavin reductase
**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
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**[[4uth]] - PpFR (mutant) + FMN <br />
**[[4uth]] - PpFR (mutant) + FMN <br />
**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
 +
**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
 +
**[[2d37]] - StFR + FMN + NAD<br />
 +
**[[2d38]] - StFR + FMN + NADP<br />
}}
}}

Current revision

Human flavin reductase complex with biliverdin IX α and NADP (PDB code 1he2)

Drag the structure with the mouse to rotate

3D structures of flavin reductase

Updated on 06-March-2023

References

  1. ↑ Yubisui T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiological concentration by NADPH-flavin reductase of human erythrocytes. J Biochem. 1980 Jun;87(6):1715-20. PMID:7400118
  2. ↑ Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564 doi:10.1038/84948

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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