1k3v
From Proteopedia
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'''Porcine Parvovirus Capsid''' | '''Porcine Parvovirus Capsid''' | ||
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[[Category: Tijssen, P.]] | [[Category: Tijssen, P.]] | ||
[[Category: Zadori, Z.]] | [[Category: Zadori, Z.]] | ||
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Revision as of 19:16, 2 May 2008
Porcine Parvovirus Capsid
Overview
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions.
About this Structure
1K3V is a Single protein structure of sequence from Porcine parvovirus. Full crystallographic information is available from OCA.
Reference
The structure of porcine parvovirus: comparison with related viruses., Simpson AA, Hebert B, Sullivan GM, Parrish CR, Zadori Z, Tijssen P, Rossmann MG, J Mol Biol. 2002 Feb 1;315(5):1189-98. PMID:11827486 Page seeded by OCA on Fri May 2 22:16:19 2008
