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2mlr

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==Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Alpha-face==
==Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Alpha-face==
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<StructureSection load='2mlr' size='340' side='right'caption='[[2mlr]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
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<StructureSection load='2mlr' size='340' side='right'caption='[[2mlr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MLR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PX4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PX4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2poj|2poj]], [[2mls|2mls]]</div></td></tr>
 
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP12, HME ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlr OCA], [https://pdbe.org/2mlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlr RCSB], [https://www.ebi.ac.uk/pdbsum/2mlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mlr OCA], [https://pdbe.org/2mlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mlr RCSB], [https://www.ebi.ac.uk/pdbsum/2mlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mlr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Macrophage elastase]]
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[[Category: Fulcher YG]]
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[[Category: Doren, S R.Van]]
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[[Category: Koppisetti RK]]
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[[Category: Fulcher, Y G]]
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[[Category: Lenoir M]]
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[[Category: Koppisetti, R K]]
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[[Category: Overduin M]]
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[[Category: Lenoir, M]]
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[[Category: Prior SH]]
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[[Category: Overduin, M]]
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[[Category: Van Doren SR]]
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[[Category: Prior, S H]]
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[[Category: Catalytic domain]]
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[[Category: Hydrolase]]
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[[Category: Membrane-binding of soluble metalloproteinase mmp-12]]
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Revision as of 08:00, 8 March 2023

Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Alpha-face

PDB ID 2mlr

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