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2n0o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n0o is ON HOLD Authors: Alves, E.S.F., Oliveira, A.L., Alves, E.S.F. Description: NMR Solution Structure and Model Membrane Interaction Studies of...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR Solution Structure and Model Membrane Interaction Studies of the Peptide Hylin a1 from the Arboreal South American Frog Hypsiboas albopunctatus== | |
| + | <StructureSection load='2n0o' size='340' side='right'caption='[[2n0o]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Boana_albopunctata Boana albopunctata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N0O FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0o OCA], [https://pdbe.org/2n0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n0o RCSB], [https://www.ebi.ac.uk/pdbsum/2n0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n0o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALBO1_BOAAL ALBO1_BOAAL] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Antimicrobial peptides (AMPs) appear as a promising therapeutic candidate against multi-resistant pathogens, because they are able to kill microorganisms and have low toxicity of resistance cells. Hylin a1 (Hy-a1, IFGAILPLALGALKNLIK-NH2) is a peptide extracted from the skin secretion of the frog Hypsiboas albopunctatus, which displays antimicrobial and hemolytic activities. We report here structural studies of Hy-a1 using different techniques such as fluorescence, CD and NMR. Our data showed that Hy-a1 acquires a well defined amphipathic alpha-helix when interacting with a membrane-like environment. Furthermore, Hy-a1 presented different affinity when compared to membranes of zwitter ionic or anionic lipid composition. Finally, we proposed a molecular interaction model of this peptide with micelles. | ||
| - | + | Micelle Bound Structure and Model Membrane Interaction Studies of the Peptide Hylin a1 from the Arboreal South American Frog Hypsiboas albopunctatus.,Fernandes Alves ES, Junior EC, Cilli EM, Castro MS, Fontes W, de Magalhaes MT, Liao LM, de Oliveira AL Protein Pept Lett. 2015 Jun 9. PMID:26059694<ref>PMID:26059694</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n0o" style="background-color:#fffaf0;"></div> |
| - | [[Category: Alves | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Boana albopunctata]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alves ESF]] | ||
| + | [[Category: Oliveira AL]] | ||
Current revision
NMR Solution Structure and Model Membrane Interaction Studies of the Peptide Hylin a1 from the Arboreal South American Frog Hypsiboas albopunctatus
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