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4rro
From Proteopedia
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==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ||
| - | <StructureSection load='4rro' size='340' side='right' caption='[[4rro]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4rro' size='340' side='right'caption='[[4rro]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rro]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRO OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4rro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RRO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UX:(4S,4AR,10AS)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1,4A-DIMETHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3UX:(4S,4AR,10AS)-2-AMINO-8-(2-FLUOROPYRIDIN-3-YL)-1,4A-DIMETHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[IMIDAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-5(1H)-ONE'>3UX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rro OCA], [https://pdbe.org/4rro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rro RCSB], [https://www.ebi.ac.uk/pdbsum/4rro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rro ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4rro" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Brown | + | [[Category: Large Structures]] |
| - | [[Category: Burkard | + | [[Category: Brown KD]] |
| - | [[Category: Cox | + | [[Category: Burkard M]] |
| - | [[Category: DeLisle | + | [[Category: Cox AA]] |
| - | [[Category: | + | [[Category: DeLisle RK]] |
| - | [[Category: | + | [[Category: Dutcher D]] |
| - | [[Category: Groneberg | + | [[Category: Geck Do MK]] |
| - | [[Category: Hunt | + | [[Category: Groneberg R]] |
| - | [[Category: Liao | + | [[Category: Hunt KW]] |
| - | [[Category: Liu | + | [[Category: Liao J]] |
| - | [[Category: Lyssikatos | + | [[Category: Liu X]] |
| - | [[Category: Newhouse | + | [[Category: Lyssikatos JP]] |
| - | [[Category: Otten | + | [[Category: Newhouse B]] |
| - | [[Category: Purkey | + | [[Category: Otten JN]] |
| - | [[Category: Rana | + | [[Category: Purkey HE]] |
| - | [[Category: Regal | + | [[Category: Rana S]] |
| - | [[Category: Rhodes | + | [[Category: Regal K]] |
| - | [[Category: Scearce-Levie | + | [[Category: Rhodes SP]] |
| - | [[Category: Siu | + | [[Category: Scearce-Levie K]] |
| - | [[Category: Smith | + | [[Category: Siu M]] |
| - | [[Category: Thomas | + | [[Category: Smith D]] |
| - | [[Category: Vigers | + | [[Category: Thomas AA]] |
| - | [[Category: Watts | + | [[Category: Vigers GPA]] |
| - | [[Category: Wright | + | [[Category: Watts RJ]] |
| - | + | [[Category: Wright AD]] | |
| - | + | ||
Current revision
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
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Categories: Homo sapiens | Large Structures | Brown KD | Burkard M | Cox AA | DeLisle RK | Dutcher D | Geck Do MK | Groneberg R | Hunt KW | Liao J | Liu X | Lyssikatos JP | Newhouse B | Otten JN | Purkey HE | Rana S | Regal K | Rhodes SP | Scearce-Levie K | Siu M | Smith D | Thomas AA | Vigers GPA | Watts RJ | Wright AD
