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4rtd
From Proteopedia
(Difference between revisions)
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<StructureSection load='4rtd' size='340' side='right'caption='[[4rtd]], [[Resolution|resolution]] 3.65Å' scene=''> | <StructureSection load='4rtd' size='340' side='right'caption='[[4rtd]], [[Resolution|resolution]] 3.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rtd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4rtd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RTD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rtd OCA], [https://pdbe.org/4rtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rtd RCSB], [https://www.ebi.ac.uk/pdbsum/4rtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rtd ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A2MG_ECOLI A2MG_ECOLI] Protects the bacterial cell from host peptidases (PubMed:18697741, PubMed:26143919, PubMed:26100869). Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase (PubMed:26143919, PubMed:26100869). Trapped peptidases are still active except against very large substrates (PubMed:26100869). May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases (PubMed:26100869).<ref>PMID:18697741</ref> <ref>PMID:26100869</ref> <ref>PMID:26143919</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cogdell | + | [[Category: Cogdell RJ]] |
| - | [[Category: Fyfe | + | [[Category: Fyfe CD]] |
| - | [[Category: Grinter | + | [[Category: Grinter R]] |
| - | [[Category: Josts | + | [[Category: Josts I]] |
| - | [[Category: Roszak | + | [[Category: Roszak AW]] |
| - | [[Category: Walker | + | [[Category: Walker D]] |
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Current revision
Escherichia coli alpha-2-macroglobulin activated by porcine elastase
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