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Complement C4

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<StructureSection load='4fxk' size='340' side='right' caption='Glycosylated human complement C4-A α chain (grey), C4 β (green) and γ chain (pink) (PDB code [[4fxk]]) ' scene=''>
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<StructureSection load='5jpn' size='340' side='right' caption='Glycosylated human complement C4-A α chain (grey), C4 β (green) and γ chain (pink) (PDB code [[5jpn]]) ' scene=''>
== Function ==
== Function ==
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[[5jpm]] – hCC4a + mannan-binding lectin serine protease<br />
[[5jpm]] – hCC4a + mannan-binding lectin serine protease<br />
[[4xam]] – hCC4a residues 757-1744 + hCC4-B residues 20-675<br />
[[4xam]] – hCC4a residues 757-1744 + hCC4-B residues 20-675<br />
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[[4fxk]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains<br />
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[[5jpn]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains<br />
[[4fxg]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease<br />
[[4fxg]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease<br />
[[6ysq]] – hCC4b + nanobody<br />
[[6ysq]] – hCC4b + nanobody<br />

Revision as of 19:07, 11 March 2023

Glycosylated human complement C4-A α chain (grey), C4 β (green) and γ chain (pink) (PDB code 5jpn)

Drag the structure with the mouse to rotate

3D structures of complement C4

Updated on 11-March-2023

5jpn, 5jtw – hCC4a- human
1hzf – hCC4a residues 970-1336
5jpm – hCC4a + mannan-binding lectin serine protease
4xam – hCC4a residues 757-1744 + hCC4-B residues 20-675
5jpn – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains
4fxg – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease
6ysq – hCC4b + nanobody
7b2m, 7b2p, 7b2q – hCC4b + nanobody – Cryo EM

References

  1. ↑ Nesargikar PN, Spiller B, Chavez R. The complement system: history, pathways, cascade and inhibitors. Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11. doi:, 10.1556/EuJMI.2.2012.2.2. Epub 2012 Jun 13. PMID:24672678 doi:http://dx.doi.org/10.1556/EuJMI.2.2012.2.2
  2. ↑ Chen Z, Koralov SB, Kelsoe G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med. 2000 Nov 6;192(9):1339-52. PMID:11067882
  3. ↑ Hou S, Qi J, Liao D, Zhang Q, Fang J, Zhou Y, Liu Y, Bai L, Zhang M, Kijlstra A, Yang P. Copy number variations of complement component C4 are associated with Behcet's disease but not with ankylosing spondylitis associated with acute anterior uveitis. Arthritis Rheum. 2013 Nov;65(11):2963-70. doi: 10.1002/art.38116. PMID:23918728 doi:http://dx.doi.org/10.1002/art.38116
  4. ↑ Chowdhury SJ, Karra VK, Bharali R, Kar P. Role of complement component C4 in treatment response and disease progression in chronic hepatitis C patients. J Viral Hepat. 2015 Aug;22(8):671-4. doi: 10.1111/jvh.12383. Epub 2015 Jan 9. PMID:25573496 doi:http://dx.doi.org/10.1111/jvh.12383

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Michal Harel, Joel L. Sussman

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