Introduction

Sodium-taurocholate Co-transporting Polypeptide (NTCP) is found within the membrane of hepatocyte, and its primary role is to facilitate the transport of bile salts into hepatocytes from the bloodstream. This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile salts to solubilize fats for digestion. In addition to transporting bile salts into the cytoplasm of hepatocytes, NTCP also serves as a receptor for Hepatitis B (HBV) and Hepatitis D (HDV) viruses.

Function

Bile Salt Uptake

HBV/HDV Infection

Structure

Proline/Glycine Hinge

Core & Panel Domains

Sodium Binding Sites

Significant Residues

Molecular Mechanism

Mechanism of Bile Salt Uptake

Mechanism of HBV/HDV Infection

Medical Relevance

Relevance

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