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5ool

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(New page: ==Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA== <StructureSection load='5ool' size='340' side='right' caption='5ool,...)
Current revision (09:56, 15 March 2023) (edit) (undo)
 
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==Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA==
==Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA==
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<StructureSection load='5ool' size='340' side='right' caption='[[5ool]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
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<SX load='5ool' size='340' side='right' viewer='molstar' caption='[[5ool]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ool]] is a 55 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OOL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ool]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OOL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ool FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ool OCA], [https://pdbe.org/5ool PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ool RCSB], [https://www.ebi.ac.uk/pdbsum/5ool PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ool ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ool FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ool OCA], [http://pdbe.org/5ool PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ool RCSB], [http://www.ebi.ac.uk/pdbsum/5ool PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ool ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/RM03_HUMAN RM03_HUMAN]] Combined oxidative phosphorylation defect type 9. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/RM44_HUMAN RM44_HUMAN]] Infantile hypertrophic cardiomyopathy due to MRPL44 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RM18_HUMAN RM18_HUMAN]] Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.<ref>PMID:21685364</ref> [[http://www.uniprot.org/uniprot/ICT1_HUMAN ICT1_HUMAN]] Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.<ref>PMID:20186120</ref> [[http://www.uniprot.org/uniprot/RM14_HUMAN RM14_HUMAN]] Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).<ref>PMID:22829778</ref> [[http://www.uniprot.org/uniprot/RM36_HUMAN RM36_HUMAN]] Component of the large subunit of the mitochondrial ribosome. [[http://www.uniprot.org/uniprot/G45IP_HUMAN G45IP_HUMAN]] Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. [[http://www.uniprot.org/uniprot/RM16_HUMAN RM16_HUMAN]] Component of the large subunit of mitochondrial ribosome. [[http://www.uniprot.org/uniprot/RM41_HUMAN RM41_HUMAN]] Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.<ref>PMID:16024796</ref> <ref>PMID:16256947</ref> [[http://www.uniprot.org/uniprot/ACPM_HUMAN ACPM_HUMAN]] Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity). [[http://www.uniprot.org/uniprot/RM44_HUMAN RM44_HUMAN]] Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.<ref>PMID:23315540</ref> [[http://www.uniprot.org/uniprot/MASU1_HUMAN MASU1_HUMAN]] May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.<ref>PMID:22238376</ref>
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[https://www.uniprot.org/uniprot/RM02_HUMAN RM02_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ool" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ool" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Aminoacyl-tRNA hydrolase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aibara, S]]
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[[Category: Large Structures]]
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[[Category: Amunts, A]]
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[[Category: Aibara S]]
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[[Category: Bai, X C]]
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[[Category: Amunts A]]
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[[Category: Brown, A]]
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[[Category: Bai XC]]
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[[Category: Kimanius, D]]
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[[Category: Brown A]]
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[[Category: Ramakrishnan, V]]
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[[Category: Kimanius D]]
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[[Category: Rathore, S]]
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[[Category: Ramakrishnan V]]
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[[Category: Rorbach, J]]
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[[Category: Rathore S]]
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[[Category: Biogenesis]]
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[[Category: Rorbach J]]
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[[Category: Electron cryomicroscopy]]
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[[Category: Mitochondria]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Current revision

Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA

5ool, resolution 3.06Å

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