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2n5z

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==Mycobacterium tuberculosis: a dynamic view of the resuscitation promoting factor RpfC catalytic domain==
==Mycobacterium tuberculosis: a dynamic view of the resuscitation promoting factor RpfC catalytic domain==
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<StructureSection load='2n5z' size='340' side='right' caption='[[2n5z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n5z' size='340' side='right'caption='[[2n5z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N5Z FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTCY180.34, rpfC, Rv1884c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n5z OCA], [https://pdbe.org/2n5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n5z RCSB], [https://www.ebi.ac.uk/pdbsum/2n5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n5z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n5z OCA], [http://pdbe.org/2n5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n5z RCSB], [http://www.ebi.ac.uk/pdbsum/2n5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n5z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPFC_MYCTU RPFC_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref>
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[https://www.uniprot.org/uniprot/RPFC_MYCTU RPFC_MYCTU] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Isernia, C]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Maione, V]]
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[[Category: Isernia C]]
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[[Category: Russo, L]]
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[[Category: Maione V]]
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[[Category: Hydrolase]]
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[[Category: Russo L]]
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[[Category: Resuscitation promoting factor]]
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[[Category: Rpfc]]
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Current revision

Mycobacterium tuberculosis: a dynamic view of the resuscitation promoting factor RpfC catalytic domain

PDB ID 2n5z

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