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2n7b

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==Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx==
==Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx==
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<StructureSection load='2n7b' size='340' side='right' caption='[[2n7b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n7b' size='340' side='right'caption='[[2n7b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0D8:3-AMINOPROPAN-1-OL'>0D8</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0D8:3-AMINOPROPAN-1-OL'>0D8</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7a|2n7a]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7b OCA], [https://pdbe.org/2n7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7b RCSB], [https://www.ebi.ac.uk/pdbsum/2n7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7b ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIGLEC8, SAF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7b OCA], [http://pdbe.org/2n7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7b RCSB], [http://www.ebi.ac.uk/pdbsum/2n7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7b ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN]] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
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[https://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Allain, F H.T]]
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[[Category: Large Structures]]
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[[Category: Ernst, B]]
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[[Category: Allain FH-T]]
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[[Category: Proepster, J M]]
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[[Category: Ernst B]]
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[[Category: Rabbani, S]]
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[[Category: Proepster JM]]
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[[Category: Schubert, M]]
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[[Category: Rabbani S]]
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[[Category: Yang, F]]
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[[Category: Schubert M]]
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[[Category: Carbohydrate recognition]]
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[[Category: Yang F]]
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[[Category: Carbohydrate-binding receptor]]
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[[Category: I-type lectin]]
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[[Category: Protein-glycan complex]]
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[[Category: Saf-2]]
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[[Category: Sialic acid-binding immunoglobulin-like lectin 8]]
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[[Category: Siglec8]]
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[[Category: Structural protein]]
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[[Category: Sulfated sialyl lewis x]]
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Current revision

Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx

PDB ID 2n7b

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