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2n99

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==Solution structure of the SLURP-2, a secreted isoform of Lynx1==
==Solution structure of the SLURP-2, a secreted isoform of Lynx1==
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<StructureSection load='2n99' size='340' side='right' caption='[[2n99]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n99' size='340' side='right'caption='[[2n99]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N99 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N99 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LYNX1, SLURP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [https://pdbe.org/2n99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [https://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [http://pdbe.org/2n99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [http://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LYNX1_HUMAN LYNX1_HUMAN]] Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.<ref>PMID:16575903</ref>
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[https://www.uniprot.org/uniprot/SLUR2_HUMAN SLUR2_HUMAN] Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.<ref>PMID:16575903</ref> <ref>PMID:27485575</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arseniev, A S]]
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[[Category: Large Structures]]
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[[Category: Lyukmanova, E N]]
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[[Category: Arseniev AS]]
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[[Category: Paramonov, A S]]
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[[Category: Lyukmanova EN]]
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[[Category: Shenkarev, Z O]]
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[[Category: Paramonov AS]]
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[[Category: Cell proliferation]]
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[[Category: Shenkarev ZO]]
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[[Category: Epithelium]]
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[[Category: Keratinocyte]]
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[[Category: Muscarinic acetylcholine receptor]]
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[[Category: Neuromodulator]]
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[[Category: Neuropeptide]]
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[[Category: Nicotinic acetylcholine receptor]]
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[[Category: Three-finger protein]]
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Current revision

Solution structure of the SLURP-2, a secreted isoform of Lynx1

PDB ID 2n99

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