Glutathione peroxidase

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Line 34: Line 34:
*GPX4
*GPX4
-
**[[2gs3]], [[2obi]] – hGPX4 (mutant)<br />
+
**[[2gs3]], [[2obi]], [[6elw]], [[7l8k]], [[7l8l]], [[7l8m]], [[7l8q, [[7l8r]] – hGPX4 (mutant)<br />
**[[5h5q]] – hGPX4 + GXPEP-1<br />
**[[5h5q]] – hGPX4 + GXPEP-1<br />
**[[5h5r]] – hGPX4 (mutant) + GXPEP-2<br />
**[[5h5r]] – hGPX4 (mutant) + GXPEP-2<br />
**[[5h5s]] – hGPX4 (mutant) + GXPEP-3<br />
**[[5h5s]] – hGPX4 (mutant) + GXPEP-3<br />
**[[6hkq]], [[6hn3]] – hGPX4 + inhibitor<br />
**[[6hkq]], [[6hn3]] – hGPX4 + inhibitor<br />
-
**[[5l71]] – GPX4 - mouse<br />
+
**[[5l71]] – mGPX4 - mouse<br />
*GPX5
*GPX5
Line 46: Line 46:
**[[2p5q]], [[2p5r]] – GPX5 – poplar
**[[2p5q]], [[2p5r]] – GPX5 – poplar
 +
 +
*GPX6
 +
 +
**[[7fc2]] – mGPX6<br />
*GPX7
*GPX7

Revision as of 11:03, 16 March 2023

Glutatione peroxidase 1 complex with glycerol and ammonium ion, 3e0u

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3D Structures of glutathione peroxidase

Updated on 16-March-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

  • GPX1
    • 2f8a – hGPX1 (mutant) – human
    • 3e0u – GPX1 – Trypanosoma cruzi
  • GPX2
    • 2he3 – hGPX2 (mutant)
  • GPX3
    • 2r37 – hGPX3 (mutant)
    • 3cmi – GPX3 – yeast
  • GPX4
  • GPX5
  • GPX6
  • GPX7
  • GPX8
  • GPX
    • 1gp1 – GPX + amino-selenino-propionic acid – bovine
    • 2v1m – SmGPX – Schistosoma mansoni
    • 2wgr – SmGPX (mutant)
    • 6vpd – GPX – Hypocrea jecorina

}}

References

  1. Arthur JR. The glutathione peroxidases. Cell Mol Life Sci. 2000 Dec;57(13-14):1825-35. PMID:11215509
  2. Lei XG, Cheng WH, McClung JP. Metabolic regulation and function of glutathione peroxidase-1. Annu Rev Nutr. 2007;27:41-61. PMID:17465855 doi:http://dx.doi.org/10.1146/annurev.nutr.27.061406.093716
  3. Ran Q, Liang H, Ikeno Y, Qi W, Prolla TA, Roberts LJ 2nd, Wolf N, Van Remmen H, Richardson A. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):932-42. PMID:17895430
  4. Hall L, Williams K, Perry AC, Frayne J, Jury JA. The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. Biochem J. 1998 Jul 1;333 ( Pt 1):5-9. PMID:9639555
  5. Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut. 2012 Sep;61(9):1250-60. doi: 10.1136/gutjnl-2011-301078. Epub 2011 Dec 9. PMID:22157330 doi:http://dx.doi.org/10.1136/gutjnl-2011-301078
  6. Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S, Mano H. Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep. 2008 Dec;20(6):1299-303. PMID:19020706
  7. Ran Q, Gu M, Van Remmen H, Strong R, Roberts JL, Richardson A. Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res. 2006 Jul;84(1):202-8. PMID:16673405 doi:http://dx.doi.org/10.1002/jnr.20868
  8. Peng D, Hu T, Soutto M, Belkhiri A, Zaika A, El-Rifai W. Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut. 2014 Apr;63(4):540-51. doi: 10.1136/gutjnl-2013-304612. Epub 2013 Apr 12. PMID:23580780 doi:http://dx.doi.org/10.1136/gutjnl-2013-304612

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