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1k8k
From Proteopedia
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[[Image:1k8k.gif|left|200px]] | [[Image:1k8k.gif|left|200px]] | ||
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'''Crystal Structure of Arp2/3 Complex''' | '''Crystal Structure of Arp2/3 Complex''' | ||
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[[Category: Robinson, R C.]] | [[Category: Robinson, R C.]] | ||
[[Category: Turbedsky, K.]] | [[Category: Turbedsky, K.]] | ||
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Revision as of 19:26, 2 May 2008
Crystal Structure of Arp2/3 Complex
Overview
We determined a crystal structure of bovine Arp2/3 complex, an assembly of seven proteins that initiates actin polymerization in eukaryotic cells, at 2.0 angstrom resolution. Actin-related protein 2 (Arp2) and Arp3 are folded like actin, with distinctive surface features. Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains. ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament. ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits. We predict that WASp/Scar proteins activate Arp2/3 complex by bringing Arp2 into proximity with Arp3 for nucleation of a branch on the side of a preexisting actin filament.
About this Structure
1K8K is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Crystal structure of Arp2/3 complex., Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD, Science. 2001 Nov 23;294(5547):1679-84. PMID:11721045 Page seeded by OCA on Fri May 2 22:26:13 2008
