7z3q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.== | |
| - | + | <StructureSection load='7z3q' size='340' side='right'caption='[[7z3q]], [[Resolution|resolution]] 3.62Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7z3q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z3Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z3q OCA], [https://pdbe.org/7z3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z3q RCSB], [https://www.ebi.ac.uk/pdbsum/7z3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z3q ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LEP_HUMAN LEP_HUMAN] Defects in LEP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9500540</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LEP_HUMAN LEP_HUMAN] May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Alexandra T]] | ||
| + | [[Category: Savvides SN]] | ||
| + | [[Category: Verschueren K]] | ||
| + | [[Category: Verstraete K]] | ||
Revision as of 07:18, 22 March 2023
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
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