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8c02

From Proteopedia

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Current revision (07:22, 22 March 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8c02 is ON HOLD until Paper Publication
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==Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation==
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<StructureSection load='8c02' size='340' side='right'caption='[[8c02]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C02 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c02 OCA], [https://pdbe.org/8c02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c02 RCSB], [https://www.ebi.ac.uk/pdbsum/8c02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c02 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]<ref>PMID:15692071</ref> <ref>PMID:22682227</ref> <ref>PMID:29237594</ref> <ref>PMID:32814342</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Drozdzyk K]]
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[[Category: Dutzler R]]
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[[Category: Lehmann EF]]
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[[Category: Liziczai M]]
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[[Category: Manatschal C]]

Current revision

Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation

PDB ID 8c02

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OCA

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