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4uhy

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==Crystal structure of the human RGMA-BMP2 complex==
==Crystal structure of the human RGMA-BMP2 complex==
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<StructureSection load='4uhy' size='340' side='right' caption='[[4uhy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4uhy' size='340' side='right'caption='[[4uhy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uhy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uhy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHY FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui1|4ui1]], [[4ui2|4ui2]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhy OCA], [https://pdbe.org/4uhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhy RCSB], [https://www.ebi.ac.uk/pdbsum/4uhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhy OCA], [http://pdbe.org/4uhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhy RCSB], [http://www.ebi.ac.uk/pdbsum/4uhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMA_HUMAN RGMA_HUMAN]] Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.<ref>PMID:19273616</ref> <ref>PMID:19458235</ref>
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[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Bone morphogenetic protein|Bone morphogenetic protein]]
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bell, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bishop, B]]
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[[Category: Large Structures]]
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[[Category: Elegheert, J]]
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[[Category: Bell CH]]
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[[Category: Healey, E G]]
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[[Category: Bishop B]]
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[[Category: Padilla-Parra, S]]
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[[Category: Elegheert J]]
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[[Category: Siebold, C]]
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[[Category: Healey EG]]
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[[Category: Axon guidance]]
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[[Category: Padilla-Parra S]]
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[[Category: Bone morphogenetic protein pathway]]
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[[Category: Siebold C]]
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[[Category: Cell surface receptor signaling]]
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[[Category: Hemojuvelin]]
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[[Category: Morphogen]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the human RGMA-BMP2 complex

PDB ID 4uhy

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