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4v2b

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rat Unc5D Ig domain 1

Structural highlights

4v2b is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UNC5D_RAT Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).[UniProtKB:Q6UXZ4][UniProtKB:Q8K1S2]

Publication Abstract from PubMed

FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We apply this knowledge to elucidate FLRT functions during cortical development. We show that FLRTs regulate both the radial migration of pyramidal neurons, as well as their tangential spread. Mechanistically, radial migration is controlled by repulsive FLRT2-Unc5D interactions, while spatial organization in the tangential axis involves adhesive FLRT-FLRT interactions. Further, we show that the fundamental mechanisms of FLRT adhesion and repulsion are conserved between neurons and vascular endothelial cells. Our results reveal FLRTs as powerful guidance factors with structurally encoded repulsive and adhesive surfaces.

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.,Seiradake E, del Toro D, Nagel D, Cop F, Hartl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014, Oct 22. PMID:25374360^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Seiradake E, del Toro D, Nagel D, Cop F, Hartl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R. FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron. 2014 Oct 22;84(2):370-85. doi: 10.1016/j.neuron.2014.10.008. Epub 2014, Oct 22. PMID:25374360 doi:http://dx.doi.org/10.1016/j.neuron.2014.10.008

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4v2b"

@@ Line 1: / Line 1: @@
 ==rat Unc5D Ig domain 1==
-<StructureSection load='4v2b' size='340' side='right' caption='[[4v2b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='4v2b' size='340' side='right'caption='[[4v2b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4v2b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V2B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4v2b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2B FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2a|4v2a]], [[4v2c|4v2c]], [[4v2d|4v2d]], [[4v2e|4v2e]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2b OCA], [https://pdbe.org/4v2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2b RCSB], [https://www.ebi.ac.uk/pdbsum/4v2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2b ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2b OCA], [http://pdbe.org/4v2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v2b RCSB], [http://www.ebi.ac.uk/pdbsum/4v2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2b ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/UNC5D_RAT UNC5D_RAT] Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).[UniProtKB:Q6UXZ4][UniProtKB:Q8K1S2]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 24: @@
 __TOC__
 </StructureSection>
-[[Category: Acker-Palmer, A]]
+[[Category: Homo sapiens]]
-[[Category: Border, E C]]
+[[Category: Large Structures]]
-[[Category: Cop, F]]
+[[Category: Acker-Palmer A]]
-[[Category: Haertl, R]]
+[[Category: Border EC]]
-[[Category: Harlos, K]]
+[[Category: Cop F]]
-[[Category: Jones, E Y]]
+[[Category: Haertl R]]
-[[Category: Klein, R]]
+[[Category: Harlos K]]
-[[Category: Nagel, D]]
+[[Category: Jones EY]]
-[[Category: Ruff, T]]
+[[Category: Klein R]]
-[[Category: Seiradake, E]]
+[[Category: Nagel D]]
-[[Category: Seyit-Bremer, G]]
+[[Category: Ruff T]]
-[[Category: Toro, D del]]
+[[Category: Seiradake E]]
-[[Category: Apoptosis]]
+[[Category: Seyit-Bremer G]]
-[[Category: Flrt]]
+[[Category: Del Toro D]]
-[[Category: Ig domain]]
-[[Category: Netrin receptor]]
-[[Category: Uncoordinated-5]]

4v2b

From Proteopedia

Current revision

rat Unc5D Ig domain 1

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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