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1ki0

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[[Image:1ki0.gif|left|200px]]
[[Image:1ki0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ki0 |SIZE=350|CAPTION= <scene name='initialview01'>1ki0</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1ki0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BCN:BICINE'>BCN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] </span>
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or leave the SCENE parameter empty for the default display.
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|DOMAIN=
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{{STRUCTURE_1ki0| PDB=1ki0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ki0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki0 OCA], [http://www.ebi.ac.uk/pdbsum/1ki0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ki0 RCSB]</span>
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}}
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'''The X-ray Structure of Human Angiostatin'''
'''The X-ray Structure of Human Angiostatin'''
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[[Category: Grella, D K.]]
[[Category: Grella, D K.]]
[[Category: Tulinsky, A.]]
[[Category: Tulinsky, A.]]
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[[Category: kringle domain]]
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[[Category: Kringle domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:46:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:54 2008''
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Revision as of 19:46, 2 May 2008

Image:1ki0.gif

Template:STRUCTURE 1ki0

The X-ray Structure of Human Angiostatin


Overview

Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule of crystallization while the former of kringle 2 and kringle 3 are cofacial. Moreover, the separation of the kringle 2 and kringle 3 lysiner binding sites is sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30 found in the kringle 2/VEK-30 complex. Together the three kringles produce a central cavity suggestive of a unique domain where they may function in concert.

About this Structure

1KI0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin., Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH, J Mol Biol. 2002 May 10;318(4):1009-17. PMID:12054798 Page seeded by OCA on Fri May 2 22:46:21 2008

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