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4x4l

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<StructureSection load='4x4l' size='340' side='right'caption='[[4x4l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4x4l' size='340' side='right'caption='[[4x4l]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x4l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X4L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X4L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3XG:ETHYL+({4-OXO-3-[3-(PYRROLIDIN-1-YL)PROPYL]-3,4-DIHYDRO[1]BENZOTHIENO[3,2-D]PYRIMIDIN-2-YL}SULFANYL)ACETATE'>3XG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3XG:ETHYL+({4-OXO-3-[3-(PYRROLIDIN-1-YL)PROPYL]-3,4-DIHYDRO[1]BENZOTHIENO[3,2-D]PYRIMIDIN-2-YL}SULFANYL)ACETATE'>3XG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wp7|4wp7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4l OCA], [https://pdbe.org/4x4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x4l RCSB], [https://www.ebi.ac.uk/pdbsum/4x4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x4l ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A1, ALDC, ALDH1, PUMB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4l OCA], [http://pdbe.org/4x4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x4l RCSB], [http://www.ebi.ac.uk/pdbsum/4x4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x4l ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
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[https://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Retinal dehydrogenase]]
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[[Category: Hurley TD]]
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[[Category: Hurley, T D]]
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[[Category: Morgan CA]]
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[[Category: Morgan, C A]]
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[[Category: Oxidoreductase enzyme inhibitor]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Revision as of 21:11, 12 April 2023

Structure of human ALDH1A1 with inhibitor CM037

PDB ID 4x4l

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