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1aft

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(New page: 200px<br /><applet load="1aft" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aft" /> '''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE ...)
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[[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1aft" />
 
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'''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br />
 
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==Overview==
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==SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES==
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The structure of peptide N-AcYTLDADF when bound to the large subunit of, mouse ribonucleotide reductase has been elucidated by transfer NOE. This, structure suggests a general design for type 1 RR inhibitors.
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<StructureSection load='1aft' size='340' side='right'caption='[[1aft]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aft]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AFT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aft OCA], [https://pdbe.org/1aft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aft RCSB], [https://www.ebi.ac.uk/pdbsum/1aft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aft ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR2_MOUSE RIR2_MOUSE] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
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==About this Structure==
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NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.,Fisher A, Laub PB, Cooperman BS Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667<ref>PMID:7583667</ref>
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1AFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583667 7583667]
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</div>
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[[Category: Ribonucleoside-diphosphate reductase]]
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<div class="pdbe-citations 1aft" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Barwis, B.A.]]
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<references/>
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[[Category: Cooperman, B.S.]]
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__TOC__
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[[Category: Fisher, A.L.]]
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</StructureSection>
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[[Category: Furst, G.T.]]
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[[Category: Large Structures]]
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[[Category: Hamann, C.S.]]
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[[Category: Barwis BA]]
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[[Category: Laub, P.B.]]
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[[Category: Cooperman BS]]
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[[Category: ACE]]
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[[Category: Fisher AL]]
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[[Category: nonstandard type i turn]]
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[[Category: Furst GT]]
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[[Category: peptide inhibitors]]
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[[Category: Hamann CS]]
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[[Category: restrained molecular dynamics]]
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[[Category: Laub PB]]
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[[Category: ribonucleotide reductase]]
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[[Category: transferred noesy]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:49:18 2007''
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Current revision

SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES

PDB ID 1aft

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