This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4xjm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4xjm' size='340' side='right'caption='[[4xjm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4xjm' size='340' side='right'caption='[[4xjm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4xjm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4xjm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=41E:3-{1-[(5-ACETYLTHIOPHEN-2-YL)CARBONYL]PIPERIDIN-4-YL}-N-(3-METHOXYPHENYL)PROPANAMIDE'>41E</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=41E:3-{1-[(5-ACETYLTHIOPHEN-2-YL)CARBONYL]PIPERIDIN-4-YL}-N-(3-METHOXYPHENYL)PROPANAMIDE'>41E</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xjl|4xjl]], [[4xjo|4xjo]], [[4xjp|4xjp]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjm OCA], [https://pdbe.org/4xjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xjm RCSB], [https://www.ebi.ac.uk/pdbsum/4xjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjm ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioA, Rv1568, MTCY336.35c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjm OCA], [http://pdbe.org/4xjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xjm RCSB], [http://www.ebi.ac.uk/pdbsum/4xjm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjm ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU]] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref>
+
[https://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref>
==See Also==
==See Also==
Line 20: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Myctu]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Dai, R]]
+
[[Category: Dai R]]
-
[[Category: Finzel, B C]]
+
[[Category: Finzel BC]]
-
[[Category: Inhibitor complex transaminase plp]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Revision as of 17:39, 26 April 2023

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound

PDB ID 4xjm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xjm"
Personal tools