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4xjr

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==The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed==
==The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed==
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<StructureSection load='4xjr' size='340' side='right' caption='[[4xjr]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4xjr' size='340' side='right'caption='[[4xjr]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xjr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respirovirus_3 Human respirovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XJR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OEL:(6R)-2,6-ANHYDRO-3,4,5-TRIDEOXY-6-[(2S)-2,3-DIHYDROXYPROPANOYL]-3-FLUORO-5-[(2-METHYLPROPANOYL)AMINO]-4-TRIAZA-1,2-DIEN-2-IUM-1-YL-L-GULONIC+ACID'>OEL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OEL:(6R)-2,6-ANHYDRO-3,4,5-TRIDEOXY-6-[(2S)-2,3-DIHYDROXYPROPANOYL]-3-FLUORO-5-[(2-METHYLPROPANOYL)AMINO]-4-TRIAZA-1,2-DIEN-2-IUM-1-YL-L-GULONIC+ACID'>OEL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xjq|4xjq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjr OCA], [https://pdbe.org/4xjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xjr RCSB], [https://www.ebi.ac.uk/pdbsum/4xjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjr OCA], [http://pdbe.org/4xjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xjr RCSB], [http://www.ebi.ac.uk/pdbsum/4xjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xjr ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HN_PI3H4 HN_PI3H4] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4xjr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4xjr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Human respirovirus 3]]
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[[Category: Carroux, C]]
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[[Category: Large Structures]]
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[[Category: Chavas, L]]
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[[Category: Carroux C]]
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[[Category: Dirr, L]]
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[[Category: Chavas L]]
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[[Category: El-Deeb, I]]
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[[Category: Dirr L]]
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[[Category: Guillon, P]]
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[[Category: El-Deeb I]]
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[[Category: Itzstein, M von]]
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[[Category: Guillon P]]
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[[Category: Haemagglutinin-neuraminidase]]
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[[Category: Von Itzstein M]]
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[[Category: Human parainfluenza virus 3]]
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[[Category: Hydrolase]]
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[[Category: Sialidase mechanism]]
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Current revision

The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed

PDB ID 4xjr

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